Hoxc^tm1.1Ssp
Targeted Allele Detail

Summary

• Symbol: Hoxc^tm1.1Ssp
• Name: homeobox C cluster; targeted mutation 1.1, S Steven Potter
• MGI ID: MGI:6164645
• Synonyms: Hoxc9,10,11-
• Gene: Hoxc Location: unknown Genetic Position: Chr15, cytoband F1-F3

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262635
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Hoxc^tm1.1Ssp involves 3 genes/genome features (Hoxc11, Hoxc10, Hoxc9) View all
• Mutation details: The BAC BMQ257-D8 was used to sequentially targeted Hoxc9, Hoxc10, and Hoxc11. In all three genes a kan/neo cassette flanked by once only lox66 and lox71 was introduced into exon 1. This insertion introduced a small deletion/frameshift. In Hoxc9 and Hoxc10 the selection cassette was removed by cre mediated recombination before targeting of the subsequent gene. Thus only Hoxa11 retains the selection cassette in the final targeting vector and this was removed after targeting by cre mediated recombination. (J:262635)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxc Mutation: 1 strain or line available

Notes

es cells = SE2

References

• Original: J:262635 Drake KA, et al., Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney. Sci Rep. 2018 Apr 20;8(1):6306
• All: 2 reference(s)