Ptk2b^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Ptk2b^tm1.2Geno
• Name: PTK2 protein tyrosine kinase 2 beta; targeted mutation 1.2, Genoway
• MGI ID: MGI:6164156
• Synonyms: Pyk2^f
• Gene: Ptk2b Location: Chr14:66390706-66518501 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Ptk2b^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250330
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 15-18. An frt-flanked neomycin selection cassette was removed via Flp-mediated recombination. Exons 15-18 encode the kinase domain. (J:250330)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptk2b Mutation: 55 strains or lines available

References

• Original: J:250330 Giralt A, et al., Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model. Nat Commun. 2017 May 30;8:15592
• All: 2 reference(s)