Slco1b2^tm1Rbk
Targeted Allele Detail

Summary

• Symbol: Slco1b2^tm1Rbk
• Name: solute carrier organic anion transporter family, member 1b2; targeted mutation 1, Richard B Kim
• MGI ID: MGI:6162471
• Synonyms: OATP1B2^-
• Gene: Slco1b2 Location: Chr6:141575244-141632372 bp, + strand Genetic Position: Chr6, 72.57 cM, cytoband G1
• Alliance: Slco1b2^tm1Rbk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262368
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 6772 bp fragment spanning exon 10 to 12 was replaced with a neomycin resistance gene cassette via homologous recombination. Western blot analysis confirmed absence of protein expression. (J:262368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slco1b2 Mutation: 47 strains or lines available

References

• Original: J:262368 Zaher H, et al., Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin. Mol Pharmacol. 2008 Aug;74(2):320-9
• All: 2 reference(s)