Reg3b^em1Rxi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Reg3b^em1Rxi
• Name: regenerating islet-derived 3 beta; endonuclease-mediated mutation 1, Rongwen Xi
• MGI ID: MGI:6162466
• Synonyms: Reg3b^F
• Gene: Reg3b Location: Chr6:78347868-78350449 bp, + strand Genetic Position: Chr6, 34.76 cM, cytoband C
• Alliance: Reg3b^em1Rxi page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR/Cas9 technology introduced loxP sites flanking exons 3 and 4. (J:262366)

Tumor Data

List all tumor models in MMHCdb carrying Reg3b^em1Rxi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Reg3b Mutation: 24 strains or lines available

References

• Original: J:262366 Liu X, et al., BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. 2017 Dec;153(6):1607-1620
• All: 1 reference(s)