Pcgf2^tm1Rxi
Targeted Allele Detail

Summary

• Symbol: Pcgf2^tm1Rxi
• Name: polycomb group ring finger 2; targeted mutation 1, Rongwen Xi
• MGI ID: MGI:6162464
• Synonyms: Mel18^F
• Gene: Pcgf2 Location: Chr11:97579649-97591323 bp, - strand Genetic Position: Chr11, 61.06 cM, cytoband C1-C3
• Alliance: Pcgf2^tm1Rxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and a FRT-flanked neomycin resistance cassette followed by a second loxP site was inserted downstream of exon 5. (J:262366)

Tumor Data

List all tumor models in MMHCdb carrying Pcgf2^tm1Rxi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcgf2 Mutation: 47 strains or lines available

References

• Original: J:262366 Liu X, et al., BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. 2017 Dec;153(6):1607-1620
• All: 2 reference(s)