Klrk1^tm2Bpol
Targeted Allele Detail

Summary

• Symbol: Klrk1^tm2Bpol
• Name: killer cell lectin-like receptor subfamily K, member 1; targeted mutation 2, Bojan Polic
• MGI ID: MGI:6161424
• Synonyms: Klrk1^flox
• Gene: Klrk1 Location: Chr6:129587286-129600827 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Klrk1^tm2Bpol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247734
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neomycin cassette, leaving exons 2 and 3 floxed. (J:247734)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klrk1 Mutation: 25 strains or lines available

References

• Original: J:247734 Lenartic M, et al., NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection. J Immunol. 2017 Feb 15;198(4):1531-1542
• All: 4 reference(s)