Tcf7l1^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Tcf7l1^{tm1c(EUCOMM)Wtsi}
• Name: transcription factor 7 like 1 (T cell specific, HMG box); targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6161406
• Synonyms: Tcf7l1^fl
• Gene: Tcf7l1 Location: Chr6:72603354-72766028 bp, - strand Genetic Position: Chr6, 32.27 cM
• Alliance: Tcf7l1^{tm1c(EUCOMM)Wtsi} page
• IMPC: Tcf7l1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235736
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 72610840 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ reporter/neomycin resistance fusion gene followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 72611703. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created through subsequent flp recombinase expression in mice carrying this allele. (J:235736, J:262044)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l1 Mutation: 84 strains or lines available

References

• Original: J:235736 Masek J, et al., Tcf7l1 protects the anterior neural fold from adopting the neural crest fate. Development. 2016 Jun 15;143(12):2206-16
• All: 4 reference(s)