Gimap6^tm1.1Gwb
Targeted Allele Detail

Summary

• Symbol: Gimap6^tm1.1Gwb
• Name: GTPase, IMAP family member 6; targeted mutation 1.1, Geoffrey W Butcher
• MGI ID: MGI:6160453
• Synonyms: GIMAP6^fl
• Gene: Gimap6 Location: Chr6:48678516-48685159 bp, - strand Genetic Position: Chr6, 23.67 cM
• Alliance: Gimap6^tm1.1Gwb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262059
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed after subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2 and 3 floxed. (J:262059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gimap6 Mutation: 15 strains or lines available

References

• Original: J:262059 Pascall JC, et al., GIMAP6 is required for T cell maintenance and efficient autophagy in mice. PLoS One. 2018;13(5):e0196504
• All: 1 reference(s)