Tg(Myh6-Fhod3)IA7Ryut
Transgene Detail

Summary

• Symbol: Tg(Myh6-Fhod3)IA7Ryut
• Name: transgene insertion IA7, Ryu Takeya
• MGI ID: MGI:6160319
• Synonyms: Tg(Fhod3CM-IA)
• Transgene: Tg(Myh6-Fhod3)IA7Ryut Location: unknown
• Alliance: Tg(Myh6-Fhod3)IA7Ryut page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Fhod3)IA7Ryut expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fhod3 (MGI:1925847)

• Tg(Myh6-Fhod3)IA7Ryut expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The transgene consists of a mutant mouse cDNA, with an engineered substitution changing isoleucine codon 1127 into an alanine codon (p.Ile1127Ala), under the control of the mouse alpha myosin heavy chain promoter. Immunoblot assays indicate that the expression from this allele is around 5-fold higher than expression from the endogenous gene. The affected codon codes for the isoleucine crucial for the actin binding function of the peptide. (J:262067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:262067 Matsuyama S, et al., Interaction between cardiac myosin-binding protein C and formin Fhod3. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4386-E4395
• All: 2 reference(s)