Cyfip2^em2Kumr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cyfip2^em2Kumr
• Name: cytoplasmic FMR1 interacting protein 2; endonuclease-mediated mutation 2, Vivek Kumar
• MGI ID: MGI:6160311
• Synonyms: Cyfip2^J
• Gene: Cyfip2 Location: Chr11:46084677-46203686 bp, - strand Genetic Position: Chr11, 27.61 cM, cytoband B1.2
• Alliance: Cyfip2^em2Kumr page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: This CRISPR/Cas9-mediated A to G mutation results in the amino acid substitution of serine for phenylalanine at position 968 (F968S), which is a change back to the sequence found in the parental C57BL/6J lineage. (J:353885)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyfip2 Mutation: 61 strains or lines available

References

• Original: J:353885 Hartmann MC, et al., Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free-choice ethanol drinking but not binge-like drinking or wheel-running activity. Alcohol Clin Exp Res (Hoboken). 2023 Aug;47(8):1518-1529
• All: 1 reference(s)