Samhd1^em2Cjj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Samhd1^em2Cjj
• Name: SAM domain and HD domain, 1; endonuclease-mediated mutation 2, Christopher J Jolly
• MGI ID: MGI:6160098
• Synonyms: Samhd1^DELTA41
• Gene: Samhd1 Location: Chr2:156939454-156977016 bp, - strand Genetic Position: Chr2, 78.0 cM, cytoband H2
• Alliance: Samhd1^em2Cjj page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was targeted using paired sgRNAs and CRISPR/Cas9 technology with modified Cas9n. This resulted in a 41 bp deletion in exon 1, creating a null allele. (J:262069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Samhd1 Mutation: 37 strains or lines available

References

• Original: J:262069 Thientosapol ES, et al., SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation. Proc Natl Acad Sci U S A. 2018 May 8;115(19):4921-4926
• All: 1 reference(s)