Tg(Polr2f-MCL1)30Yen
Transgene Detail

Summary

• Symbol: Tg(Polr2f-MCL1)30Yen
• Name: transgene insertion 30, Hsin-Fang Yang-Yen
• MGI ID: MGI:6159272
• Synonyms: hMcl-1, Tg(MCL-1)30Yen
• Transgene: Tg(Polr2f-MCL1)30Yen Location: unknown
• Alliance: Tg(Polr2f-MCL1)30Yen page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Polr2f-MCL1)30Yen expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MCL1 (4170)

  Mcl1	(MGI:101769)

• Tg(Polr2f-MCL1)30Yen expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Polr2f (MGI:1349393)

• Mutation details: A mouse 712-bp HindIII-BamHI fragment containing the promoter for mouse RNA polymerase II large subunit gene (Polr2f) drives the expression of a human MCL-1 gene. (J:146246)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:146246 Yang CY, et al., Promoter knock-in mutations reveal a role of Mcl-1 in thymocyte-positive selection and tissue or cell lineage-specific regulation of Mcl-1 expression. J Immunol. 2009 Mar 1;182(5):2959-68
• All: 1 reference(s)