Mlkl^em1Hwal
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em1Hwal
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Henning Walczak
• MGI ID: MGI:6159167
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em1Hwal page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Talen-induced genome editing technology was used to create a 19 bp deletion, resulting in the introduction of a premature stop codon. (J:261640)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 34 strains or lines available

References

• Original: J:261640 Peltzer N, et al., LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature. 2018 May;557(7703):112-117
• All: 7 reference(s)