Tg(IGHM-Csnk2a1)ADcs
Transgene Detail

Summary

• Symbol: Tg(IGHM-Csnk2a1)ADcs
• Name: transgene insertion A, David C Seldin
• MGI ID: MGI:6158966
• Synonyms: EmuPmu-CK2alpha, TG.CKA, Tg(IGHM-Csnk2a1)CKADcs
• Transgene: Tg(IGHM-Csnk2a1)ADcs Location: unknown
• Alliance: Tg(IGHM-Csnk2a1)ADcs page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A transgenic construct containing the mouse immunoglobulin heavy chain constant mu (Ighm) enhancer sequence, the human IGHM promoter, cDNA encoding mouse casein kinase 2, alpha polypeptide, the SV40 intron and polyadenylation signal, and the human IGHM enhancer was microinjected into the pronuclei of fertilized oocytes. Two independent transgenic lines, TG.CKA (A) and TG.CKB (B), were established. Ribonuclease protection analysis demonstrated expression of the transgene in the lymphoid organs of mice of both lines, more strongly in thymus than in spleen. The abundance of transgene-derived mRNA in thymus was less than 10% that of the endogenous Csnk2a transcript. (J:38552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:38552 Seldin DC, et al., Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle [see comments]. Science. 1995 Feb 10;267(5199):894-7
• All: 1 reference(s)