Myzap^tm1Norf
Targeted Allele Detail

Summary

• Symbol: Myzap^tm1Norf
• Name: myocardial zonula adherens protein; targeted mutation 1, Norbert Frey
• MGI ID: MGI:6158943
• Synonyms: Mzp^-
• Gene: Myzap Location: Chr9:71411629-71499642 bp, - strand Genetic Position: Chr9, 39.85 cM
• Alliance: Myzap^tm1Norf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231032
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: Exon 1, containing the ATG translation start site, was replaced with a lacZ gene cassette and a neomycin resistance gene cassette. This creates a reporter-null allele with the reporter gene under the control of the endogenous promoter. qRT-PCR, immunoblotting and immunofluorescence experiments confirmed the lack of expression of the endogenous gene from this allele. (J:231032)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myzap Mutation: 22 strains or lines available

References

• Original: J:231032 Rangrez AY, et al., Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and beta-Catenin/GSK-3beta Protein Signaling. J Biol Chem. 2016 Feb 19;291(8):4128-43
• All: 1 reference(s)