Scarb1^tm1.1Okoch
Targeted Allele Detail

Summary

• Symbol: Scarb1^tm1.1Okoch
• Name: scavenger receptor class B, member 1; targeted mutation 1.1, Olivier Kocher
• MGI ID: MGI:6158932
• Synonyms: Srb1^deltaCT, SR-BIdeltaCT
• Gene: Scarb1 Location: Chr5:125354151-125418082 bp, - strand Genetic Position: Chr5, 64.11 cM
• Alliance: Scarb1^tm1.1Okoch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237430
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct is designed to insert a point mutation in exon 12, and an FRT-flanked neomycin resistance (neo) cassette downstream of exon 12. The point mutation at amino acid 507 results in an alanine change to a stop codon. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:237430)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Scarb1 Mutation: 54 strains or lines available

References

• Original: J:237430 Pal R, et al., Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease. Am J Physiol Heart Circ Physiol. 2016 Dec 01;311(6):H1392-H1408
• All: 3 reference(s)