Nup153^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nup153^em1(IMPC)J
• Name: nucleoporin 153; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6158658
• Gene: Nup153 Location: Chr13:46833381-46881416 bp, - strand Genetic Position: Chr13, 24.3 cM
• Alliance: Nup153^em1(IMPC)J page
• IMPC: Nup153 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 2 guide sequences GGTCAGATGCTATCACACTC and ATACCAAGATCTAGATTTAG, which resulted in a 447 bp deletion beginning at Chromosome 13 position 46,717,030 bp and ending after 46,717,476 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000456072 (exon 2) and 224 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 38 and early truncation 14 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nup153 Mutation: 107 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)