Gt(ROSA)26Sor^{tm1(SCN5A/EGFP)Pmal}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(SCN5A/EGFP)Pmal}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Paul M Allen
• MGI ID: MGI:6156904
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(SCN5A/EGFP)Pmal} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261477
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(SCN5A/EGFP)Pmal} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SCN5A (6331)

  Scn5a

  (MGI:98251)

• Mutation details: A floxed stop cassette, human SCN5A cDNA fused to EGFP and poly A sequence were inserted via homologous recombination. (J:261477)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:261477 Milam AAV, et al., Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4(+) T Cells during an Immune Response. J Immunol. 2018 May 15;200(10):3429-3437
• All: 2 reference(s)