Naxe^tm1.1Lfan
Targeted Allele Detail

Summary

• Symbol: Naxe^tm1.1Lfan
• Name: NAD(P)HX epimerase; targeted mutation 1.1, Longhou Fang
• MGI ID: MGI:6156822
• Synonyms: Apoa1bp^-
• Gene: Naxe Location: Chr3:87963827-87965802 bp, - strand Genetic Position: Chr3, 38.78 cM
• Alliance: Naxe^tm1.1Lfan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261549
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 4 Kb upstream of exon 1 and a FRT-flanked neo cassette and a second loxP site was inserted 2 Kb downstream of exon 6. Cre-mediated recombination removed exons 1-6 in the germline. Western blot analysis of white blood cell lysates confirmed absence of protein. (J:261549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Naxe Mutation: 19 strains or lines available

References

• Original: J:261549 Mao R, et al., AIBP Limits Angiogenesis Through gamma-Secretase-Mediated Upregulation of Notch Signaling. Circ Res. 2017 May 26;120(11):1727-1739
• All: 5 reference(s)