Tlr2^tm1.1Gbrt
Targeted Allele Detail

Summary

• Symbol: Tlr2^tm1.1Gbrt
• Name: toll-like receptor 2; targeted mutation 1.1, Gregory M Barton
• MGI ID: MGI:6156372
• Synonyms: TLR2GFP
• Gene: Tlr2 Location: Chr3:83743579-83749045 bp, - strand Genetic Position: Chr3, 37.4 cM
• Alliance: Tlr2^tm1.1Gbrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305328
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a hemagglutinin (HA) tag, followed by an internal ribosome entry site (IRES) fused to an enhanced green fluorescent protein (EGFP) sequence, at the 3' end of the gene. The vector also contained a loxP-flanked neomycin selection (neo) cassette. Cre-mediated recombination removed the FRT-flanked neo cassette. (J:305328)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr2 Mutation: 61 strains or lines available

References

• Original: J:305328 Price AE, et al., A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns. Immunity. 2018 Sep 18;49(3):560-575.e6
• All: 4 reference(s)