Igh^{tm4(PGT121)Nemz}
Targeted Allele Detail

Summary

• Symbol: Igh^{tm4(PGT121)Nemz}
• Name: immunoglobulin heavy chain complex; targeted mutation 4, David Nemazee
• MGI ID: MGI:6156091
• Synonyms: gIH-PGT121
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244819
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Insertion
• The endogenous D1-4 and Js were replaced with the heavy chain of PGT121. (J:244819)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:244819 Medina-Ramirez M, et al., Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo. J Exp Med. 2017 Sep 04;214(9):2573-2590
• All: 1 reference(s)