Slc5a2^m1
Spontaneous Allele Detail

Summary

• Symbol: Slc5a2^m1
• Name: solute carrier family 5 (sodium/glucose cotransporter), member 2; mutation 1
• MGI ID: MGI:6155692
• Synonyms: Slc5a2(slc)
• Gene: Slc5a2 Location: Chr7:127864855-127871602 bp, + strand Genetic Position: Chr7, 70.08 cM, cytoband F4
• Alliance: Slc5a2^m1 page

Mutation origin

• Strain of Origin: SAMP10/TaSlc

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: DNA sequencing indicated a single nucleotide deletion of coding nucleotide 1236G, which resulted in a frameshift mutation in arginine codon 412 and the introduction of a stop codon 10 codons downstream. A truncated protein of 421 amino acids is predicted, with the absence of sequences after the 8th transmembrane domain. (J:220282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc5a2 Mutation: 35 strains or lines available

References

• Original: J:220282 Unno K, et al., Novel frame-shift mutation in Slc5a2 encoding SGLT2 in a strain of senescence-accelerated mouse SAMP10. Biochem Biophys Res Commun. 2014 Nov 7;454(1):89-94
• All: 1 reference(s)