Il6^tm3307.1Arte
Targeted Allele Detail

Summary

• Symbol: Il6^tm3307.1Arte
• Name: interleukin 6; targeted mutation 3307.1, TaconicArtemis
• MGI ID: MGI:6155630
• Synonyms: Il6^RD, Il6^{tm3307(Cerulean-P2A-CD90.1)Arte}
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm3307.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260609
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into exon 2: a floxed STOP cassette, Cerulean reporter gene, P2A peptide sequence, Thy1.1 (CD90.1) cell surface marker gene, human growth hormone polyadenylation sequence and FRT-flanked selection cassette. Flp-mediated recombination removed the selection cassette. (J:260609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 41 strains or lines available

References

• Original: J:260609 Heink S, et al., Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 2017 Jan;18(1):74-85
• All: 2 reference(s)