Tlr9^tm1.1Gbrt
Targeted Allele Detail

Summary

• Symbol: Tlr9^tm1.1Gbrt
• Name: toll-like receptor 9; targeted mutation 1.1, Gregory M Barton
• MGI ID: MGI:6154643
• Synonyms: TLR9^GFP, Tlr9^HA:GFP
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^tm1.1Gbrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: An HA tag was fused to the 3' end of the gene followed by an IRES-GFP reporter via homologous recombination. The vector also contained a loxP-flanked neomycin selection (neo) cassette, which was removed by Cre-mediated recombination. (J:258639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 63 strains or lines available

References

• Original: J:258639 Roberts AW, et al., Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity. 2017 Nov 21;47(5):913-927.e6
• All: 3 reference(s)