Kpna7^em1Ionsz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kpna7^em1Ionsz
• Name: karyopherin subunit alpha 7; endonuclease-mediated mutation 1, Qiang Sun
• MGI ID: MGI:6153971
• Synonyms: Kpna7^{em1(L201F)Ionsz}
• Gene: Kpna7 Location: Chr5:144920537-144946446 bp, - strand Genetic Position: Chr5, 84.91 cM
• Alliance: Kpna7^em1Ionsz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• CRISPR/Cas9-system was used to introduce the CTG-toTTC mutation for L222F Leu to Phe. (J:332890)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpna7 Mutation: 21 strains or lines available

References

• Original: J:332890 Wang W, et al., Karyopherin alpha deficiency contributes to human preimplantation embryo arrest. J Clin Invest. 2023 Jan 17;133(2)
• All: 1 reference(s)