Nfkbie^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Nfkbie^tm1Bal
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon; targeted mutation 1, David Baltimore
• MGI ID: MGI:6153630
• Synonyms: IkappaBepsilon^-
• Gene: Nfkbie Location: Chr17:45866629-45874095 bp, + strand Genetic Position: Chr17, 22.58 cM, cytoband C
• Alliance: Nfkbie^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80039
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced amino acids 145-343 resulting in disruption of all 6 ankyrin repeats. (J:80039)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkbie Mutation: 22 strains or lines available

References

• Original: J:80039 Hoffmann A, et al., The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science. 2002 Nov 8;298(5596):1241-5
• All: 7 reference(s)