Scn4b^{em1(IMPC)Wtsi}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn4b^{em1(IMPC)Wtsi}
• Name: sodium channel, type IV, beta; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:6153611
• Gene: Scn4b Location: Chr9:45049922-45065453 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Scn4b^{em1(IMPC)Wtsi} page
• IMPC: Scn4b gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Wellcome Sanger Institute using Cas9 and guides with spacer sequences AGAGTTACTGCAGTTGCATC, CATGGGTGGCGTCCACGGAA, GAAGGGCCTTTCTGGGTACA, and GTCATCTATGTAGTGGCTTG that targeted exon(s) ENSMUSE00000404251.2. This resulted in deletion(s) of 405 bp (location: Chr9:45058912-45059316; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn4b Mutation: 21 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 4 reference(s)