Klrc1^tm1.1Cln
Targeted Allele Detail

Summary

• Symbol: Klrc1^tm1.1Cln
• Name: killer cell lectin-like receptor subfamily C, member 1; targeted mutation 1.1, Marco Colonna
• MGI ID: MGI:6153542
• Gene: Klrc1 Location: Chr6:129642978-129655936 bp, - strand Genetic Position: Chr6, 63.44 cM, cytoband G1-2
• Alliance: Klrc1^tm1.1Cln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234674
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first 4 exons were replaced with a loxP-flanked MC1-Neo cassette. Cre-mediated recombination removed the selection cassette. (J:234674)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klrc1 Mutation: 12 strains or lines available

References

• Original: J:234674 Rapaport AS, et al., The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8(+) T Cells in Response to a Lethal Poxvirus Infection. Immunity. 2015 Dec 15;43(6):1112-24
• All: 3 reference(s)