Emx2^tm1.1Nyr
Targeted Allele Detail

Summary

• Symbol: Emx2^tm1.1Nyr
• Name: empty spiracles homeobox 2; targeted mutation 1.1, Niu Yan-Ru
• MGI ID: MGI:6153518
• Synonyms: Emx2^flox
• Gene: Emx2 Location: Chr19:59447122-59453789 bp, + strand Genetic Position: Chr19, 56.28 cM
• Alliance: Emx2^tm1.1Nyr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234706
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP-flanked Neo cassette was introduced downstream of exon 2. Cre-mediated recombination removed the selection cassette, leaving exon 2 floxed. (J:234706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Emx2 Mutation: 23 strains or lines available

References

• Original: J:234706 Tian-Zhong M, et al., Critical role of Emx2 in the pluripotency - differentiation transition in male gonocytes via regulation of FGF9/NODAL pathway. Reproduction. 2016 Jun;151(6):673-81
• All: 1 reference(s)