Gt(ROSA)26Sor^{tm2(ACTB-Kcnj8*G343D)Nich}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(ACTB-Kcnj8*G343D)Nich}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Colin G Nichols
• MGI ID: MGI:6153212
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(ACTB-Kcnj8*G343D)Nich} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234096
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(ACTB-Kcnj8*G343D)Nich} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Kcnj8	includes a G343D gain-of-function mutation

• Mutation details: The targeting construct contained the chicken beta actin promoter and a modified Kcnj8 gene containing a glycine to aspartate substitution at amino acid residue 343 (G343D). This is a gain-of-function mutation. (J:234096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:234096 Levin MD, et al., KATP channel gain-of-function leads to increased myocardial L-type Ca2+ current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6773-8
• All: 1 reference(s)