Trib2^tm1.1Jyen
Targeted Allele Detail

Summary

• Symbol: Trib2^tm1.1Jyen
• Name: tribbles pseudokinase 2; targeted mutation 1.1, Jeffery Jong-Young Yen
• MGI ID: MGI:6153202
• Gene: Trib2 Location: Chr12:15841728-15866923 bp, - strand Genetic Position: Chr12, 7.25 cM
• Alliance: Trib2^tm1.1Jyen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250047
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a lacZ and loxP-flanked Neo cassette. Cre-mediated recombination excised the neomycin resistance gene, leaving the lacZ and one loxP site in intron 2. (J:250047)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trib2 Mutation: 30 strains or lines available

References

• Original: J:250047 Lin KR, et al., Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice. Sci Rep. 2016 Aug 23;6:31444
• All: 1 reference(s)