Cipc^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Cipc^tm1.1Nju
• Name: CLOCK interacting protein, circadian; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6151055
• Gene: Cipc Location: Chr12:86993817-87012136 bp, + strand Genetic Position: Chr12, 41.13 cM
• Alliance: Cipc^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244550
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of the 3' UTR of exon 4. Cre-mediated recombination removed exon 3 and 4. QRT-PCR confirmed the absence of transcript expression in the liver regardless of circadian oscillation. (J:244550)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cipc Mutation: 22 strains or lines available

References

• Original: J:244550 Qu Z, et al., Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice. Sci China Life Sci. 2015 Apr;58(4):368-72
• All: 1 reference(s)