Bace1tm1.1Yanr
Targeted Allele Detail
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Symbol: |
Bace1tm1.1Yanr |
Name: |
beta-site APP cleaving enzyme 1; targeted mutation 1.1, Riqiang Yan |
MGI ID: |
MGI:6150902 |
Synonyms: |
BACE1fl |
Gene: |
Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
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Alliance: |
Bace1tm1.1Yanr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:259749
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Parent Cell Line: |
C2 (Nagy) (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The allele was generated to insert loxP sites flanking exon 2 of the Bace1 gene. The neo cassette flanked with FLP recombinase target (FRT) sites was removed from founder mice by crossing with crossed with the FLP deleter strain.
(J:259749)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bace1 Mutation: |
27 strains or lines available
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Original: |
J:259749 Hu X, et al., BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions. J Exp Med. 2018 Mar 5;215(3):927-940 |
All: |
3 reference(s) |
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