Cyp11b1^tm1.1Jda
Targeted Allele Detail

Summary

• Symbol: Cyp11b1^tm1.1Jda
• Name: cytochrome P450, family 11, subfamily b, polypeptide 1; targeted mutation 1, Jonathan D Ashwell
• MGI ID: MGI:6150900
• Gene: Cyp11b1 Location: Chr15:74706741-74713492 bp, - strand Genetic Position: Chr15, 34.29 cM
• Alliance: Cyp11b1^tm1.1Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259797
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 35. An frt-flanked neomycin selection cassette was removed by crossing chimeric mice with beta-actin-FLPe transgenic mice (J:259797)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp11b1 Mutation: 22 strains or lines available

References

• Original: J:259797 Mittelstadt PR, et al., Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection. J Immunol. 2018 Mar 15;200(6):1988-1994
• All: 2 reference(s)