Grk2^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Grk2^tm1Itl
• Name: G protein-coupled receptor kinase 2; targeted mutation 1. Ingenious Targeting Laboratory
• MGI ID: MGI:6150832
• Synonyms: GRK2-C340S
• Gene: Grk2 Location: Chr19:4336029-4356250 bp, - strand Genetic Position: Chr19, 3.98 cM
• Alliance: Grk2^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260295
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Single point mutation
• The G in codon 340 was replaced with C, leading to Cys340Ser (C340S) mutation in exon 12. (J:260295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grk2 Mutation: 40 strains or lines available

References

• Original: J:260295 Huang ZM, et al., Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal. 2013 Oct 29;6(299):ra95
• All: 2 reference(s)