Ubr2^em1Hgu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ubr2^em1Hgu
• Name: ubiquitin protein ligase E3 component n-recognin 2; endonuclease-mediated mutation 1, MRC Human Genetics Unit
• MGI ID: MGI:6150060
• Synonyms: Ubr2^-
• Gene: Ubr2 Location: Chr17:47239221-47321482 bp, - strand Genetic Position: Chr17, 22.91 cM
• Alliance: Ubr2^em1Hgu page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology was used to mutate cysteine 121 within the UBR domain in exon 3 to a premature stop codon. Western blot analysis confirmed absence of protein in P16 testes. (J:243410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubr2 Mutation: 88 strains or lines available

References

• Original: J:243410 Crichton JH, et al., Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes. PLoS Genet. 2017 Jul;13(7):e1006904
• All: 2 reference(s)