Orai1^tm1.1Ygwa
Targeted Allele Detail

Summary

• Symbol: Orai1^tm1.1Ygwa
• Name: ORAI calcium release-activated calcium modulator 1; targeted mutation 1.1, Yousang Gwack
• MGI ID: MGI:6149978
• Synonyms: Orai1^fl
• Gene: Orai1 Location: Chr5:123153137-123168519 bp, + strand Genetic Position: Chr5, 62.72 cM
• Alliance: Orai1^tm1.1Ygwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243375
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and a FRT-flanked neomycin resistance gene cassette was inserted. Flp-mediated recombination removed the selection cassette. (J:243375)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Orai1 Mutation: 22 strains or lines available

References

• Original: J:243375 Choi D, et al., Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03;127(4):1225-1240
• All: 5 reference(s)