Ric8a^tm2.1Aks
Targeted Allele Detail

Summary

• Symbol: Ric8a^tm2.1Aks
• Name: RIC8 guanine nucleotide exchange factor A; targeted mutation 2.1, Alar Karis
• MGI ID: MGI:6149733
• Synonyms: Ric8a^F
• Gene: Ric8a Location: Chr7:140437310-140443644 bp, + strand Genetic Position: Chr7, 86.06 cM
• Alliance: Ric8a^tm2.1Aks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206422
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted upstream of exon 1 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 4. The neomcyin selection cassette was removed by transient Cre expresssion in ES cells prior to the production of mice. (J:206422)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ric8a Mutation: 29 strains or lines available

References

• Original: J:206422 Ruisu K, et al., Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death. PLoS One. 2013;8(8):e74031
• All: 2 reference(s)