Grn^tm1.2Blrl
Targeted Allele Detail

Summary

• Symbol: Grn^tm1.2Blrl
• Name: granulin; targeted mutation 1.2, Blair R Leavitt
• MGI ID: MGI:6149575
• Synonyms: Grn^-
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1.2Blrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211725
• Parent Cell Line: mEMS128 (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Parental line mouse Grn^tm1Blrl consisting of a loxP site inserted upstream of exon 3 and a cassette containing (5' to 3') a loxP site, FRT site, splice acceptor, IRES, beta-geo cassette, stop codon, polyadenylation sequence, and FRT site inserted downstream of exon 4 was crossed with Flp-deleter to remove the cassette leaving loxP flanked exons 3 and 4. The mice was further crossed with cre-deleter to remove exon 3 and 4, resulting in constitutively null mice. (J:211725)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 48 strains or lines available

References

• Original: J:211725 Petkau TL, et al., Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice. Neurobiol Aging. 2013 Nov;34(11):2548-50
• All: 3 reference(s)