Slamf6^tm1.1Vei
Targeted Allele Detail

Summary

• Symbol: Slamf6^tm1.1Vei
• Name: SLAM family member 6; targeted mutation 1.1, Andre Veillette
• MGI ID: MGI:6149227
• Gene: Slamf6 Location: Chr1:171745002-171776525 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Slamf6^tm1.1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259468
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 to 4 were replaced with a FRT-flanked neomycin cassette. Flpe-mediated recombination removed the neomycin cassette. This deletion is expected to remove both immunoglobulin-like domains and the transmembrane region. (J:259468)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slamf6 Mutation: 32 strains or lines available

References

• Original: J:259468 Wu N, et al., A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education. Nat Immunol. 2016 Apr;17(4):387-96
• All: 3 reference(s)