Dact1^tm2Yegc
Targeted Allele Detail

Summary

• Symbol: Dact1^tm2Yegc
• Name: dishevelled-binding antagonist of beta-catenin 1; targeted mutation 2, Ye-Guang Chen
• MGI ID: MGI:6148080
• Synonyms: Dpr1^fl
• Gene: Dact1 Location: Chr12:71356658-71366881 bp, + strand Genetic Position: Chr12, 29.39 cM
• Alliance: Dact1^tm2Yegc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and a neomycin selection cassette were inserted to flank exons 2 and 3. Cre-mediated deletion of exon 2 and 3 will lead to a frameshift mutation and thereby eliminate the expression of the gene. (J:258714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dact1 Mutation: 18 strains or lines available

References

• Original: J:258714 Ma B, et al., Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation. Cell Res. 2014 Aug;24(8):912-24
• All: 2 reference(s)