Mcam^tm1.1Yanx
Targeted Allele Detail

Summary

• Symbol: Mcam^tm1.1Yanx
• Name: melanoma cell adhesion molecule; targeted mutation 1.1, Xiyun Yan
• MGI ID: MGI:6148063
• Gene: Mcam Location: Chr9:44045958-44054024 bp, + strand Genetic Position: Chr9, 24.68 cM
• Alliance: Mcam^tm1.1Yanx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244575
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1. (J:244575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcam Mutation: 38 strains or lines available

References

• Original: J:244575 Chen J, et al., CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017 Sep 05;114(36):E7622-E7631
• All: 2 reference(s)