Map2k1tm1(Map2k1,Map2k2)Chrn
Targeted Allele Detail
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Symbol: |
Map2k1tm1(Map2k1,Map2k2)Chrn |
Name: |
mitogen-activated protein kinase kinase 1; targeted mutation 1, M Jean Charron |
MGI ID: |
MGI:6148035 |
Synonyms: |
Mek11neo2 |
Gene: |
Map2k1 Location: Chr9:64093066-64160887 bp, - strand Genetic Position: Chr9, 34.55 cM
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Alliance: |
Map2k1tm1(Map2k1,Map2k2)Chrn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:258488
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Epitope tag, Inserted expressed sequence, Null/knockout) |
Mutation: |
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Insertion
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Map2k1tm1(Map2k1,Map2k2)Chrn expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Map2k1 (MGI:1346866) |
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Mutation details: A cDNA of Map2k1 (tagged with Myc and flanked by loxP sites), an frt-flanked neomycin selection cassette, and a cDNA of Map2k2 were inserted into the first exon of Mek1. Western blot analysis showed that both endogenous Map2k1 protein and the Myc-tagged Map2k1 protein are expressed in heterozygous embryonic stem (ES) cells.
(J:258488)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Map2k1 Mutation: |
92 strains or lines available
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Original: |
J:258488 Aoidi R, et al., Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect. Sci Signal. 2016 Jan 26;9(412):ra9 |
All: |
1 reference(s) |
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