Naip2^em2Fsha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Naip2^em2Fsha
• Name: NLR family, apoptosis inhibitory protein 2; endonuclease-mediated mutation 2, Feng Shao
• MGI ID: MGI:6147851
• Gene: Naip2 Location: Chr13:100280571-100338600 bp, - strand Genetic Position: Chr13, 53.01 cM, cytoband D1-D3
• Alliance: Naip2^em2Fsha page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-mediated genome editing generated a 10 bp deletion in exon 11 beginning in the glutamine at amino acid 417, deleting AAGGGCGTGG, that is predicted to produce a nonfunctional protein. (J:233312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Naip2 Mutation: 120 strains or lines available

References

• Original: J:233312 Zhao Y, et al., Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice. J Exp Med. 2016 May 2;213(5):647-56
• All: 1 reference(s)