Scn9a^tm2.1Jwo
Targeted Allele Detail

Summary

• Symbol: Scn9a^tm2.1Jwo
• Name: sodium channel, voltage-gated, type IX, alpha; targeted mutation 2.1, John N Wood
• MGI ID: MGI:6147829
• Synonyms: NaV1.7^TAP
• Gene: Scn9a Location: Chr2:66310424-66465306 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn9a^tm2.1Jwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258321
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Epitope tag, No functional change)
• Mutation: Insertion
• Mutation details: A TAP-tag containing a HAT domain, a TEV cleavage site and 3x FLAG-tags and a floxed neo cassette were inserted into the open reading frame at the 3'-end prior to the stop codon in exon 27. Cre mediated recombination removed the neo cassette. (J:258321)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn9a Mutation: 124 strains or lines available

References

• Original: J:258321 Kanellopoulos AH, et al., Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice. EMBO J. 2018 Feb 1;37(3):427-445
• All: 2 reference(s)