Grb10^tm1.1Daly
Targeted Allele Detail

Summary

• Symbol: Grb10^tm1.1Daly
• Name: growth factor receptor bound protein 10; targeted mutation 1.1, Roger J Daly
• MGI ID: MGI:6147817
• Synonyms: Grb10^flox
• Gene: Grb10 Location: Chr11:11880499-11987428 bp, - strand Genetic Position: Chr11, 7.15 cM
• Alliance: Grb10^tm1.1Daly page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258327
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked pgk-neo cassette and loxP site were inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette. (J:258327)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb10 Mutation: 53 strains or lines available

References

• Original: J:258327 Holt LJ, et al., Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice. Endocrinology. 2018 Mar 1;159(3):1339-1351
• All: 1 reference(s)