Kdm5b^tm1Jtpu
Targeted Allele Detail

Summary

• Symbol: Kdm5b^tm1Jtpu
• Name: lysine demethylase 5B; targeted mutation 1, Joyce Taylor-Papadimitriou
• MGI ID: MGI:6147722
• Synonyms: D-ARID
• Gene: Kdm5b Location: Chr1:134487916-134560621 bp, + strand Genetic Position: Chr1, 58.24 cM, cytoband E4
• Alliance: Kdm5b^tm1Jtpu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258483
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exons 2 through 4, which codes for part of the JmjN domain and the entire ARID domain. (J:258483)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm5b Mutation: 202 strains or lines available

References

• Original: J:258483 Catchpole S, et al., PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells. Int J Oncol. 2011 May;38(5):1267-77
• All: 2 reference(s)