Gsdmd^em1Broz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdmd^em1Broz
• Name: gasdermin D; endonuclease-mediated mutation 1, Petr Broz
• MGI ID: MGI:6147720
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^em1Broz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted of 2bp in exon 2. (J:258482)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 35 strains or lines available

References

• Original: J:258482 Santos JC, et al., LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J. 2018 Mar 15;37(6)
• All: 10 reference(s)