Izumo1^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Izumo1^em1Osb
• Name: izumo sperm-egg fusion 1; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka
• MGI ID: MGI:6147694
• Synonyms: deltaCyt, Izumo1^em1Maik, Izumo1^{em1(S346Stop)Osb}
• Gene: Izumo1 Location: Chr7:45270251-45276653 bp, + strand Genetic Position: Chr7, 29.39 cM, cytoband B2
• Alliance: Izumo1^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: A single point insertion was introduced that modified the final exon of the gene. A single T insertion resulted in a premature stop codon, thus is predicted to produce a truncated protein that lacks the cytoplasmic tail. (J:258196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Izumo1 Mutation: 24 strains or lines available

References

• Original: J:258196 Young SA, et al., CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility. Reproduction. 2016 Dec;152(6):665-672
• All: 1 reference(s)