Tg(TCF/Lef1-EGFP)1Kudo
Transgene Detail

Summary

• Symbol: Tg(TCF/Lef1-EGFP)1Kudo
• Name: transgene insertion 1, Akira Kudo
• MGI ID: MGI:6147687
• Synonyms: ins-TOPEGFP
• Transgene: Tg(TCF/Lef1-EGFP)1Kudo Location: unknown
• Alliance: Tg(TCF/Lef1-EGFP)1Kudo page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains the EGFP (enhanced green fluorescent protein) gene under the control of a promoter consisting of six consensus lymphoid enhancer binding factor 1/transcription factor 3 (LEF/TCF)-binding motifs upstream of a minimal TK promoter, followed by a polyadenylation signal. The entire construct was flanked by two copies of insulator core elements to minimize positional effects imposed by chromosome structure. This construct is responsive to canonical Wnt/beta-catenin signal transduction. (J:258203)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:258203 Moriyama A, et al., GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen. Genesis. 2007 Feb;45(2):90-100
• All: 2 reference(s)